Place the tube tip vertically against the skin at the base of the skull of the cat. Compare. How to use Bravecto Spot-on for Cats Ensure the animal's back is horizontal. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. INDICATIONS . (fluralaner and moxidectin topical solution) for Cats. Bravecto Plus should be administered topically as a single dose every 2 months according to the Dosage Schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Additional signs, including blurred vision and disorientation, occurred after taking an antihistamine. The cap should be rotated clockwise or counter clockwise one full turn. Step 1: Immediately before use, open the pouch and remove the tube. For topical use only. If the product accidentally contacts skin and a sticky residue persists after washing, rubbing alcohol (70% isopropyl alcohol) can be applied to the area to remove the residue. The chemical name of moxidection is (2aE,4E,5'R,6R,6'S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-[(E)-1,3-Dimethyl-1-butenyl]-5',6,6',7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5',6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran]-4',17(3'H)-dione 4'-(E)-(O-methyloxime). Do not eat, drink or smoke while handling the product. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. It binds to gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels of the nerves and muscles of the parasite resulting in hyperpolarization, paralysis and death. 6 Items. Place the tube tip vertically against the skin at the base of the skull of the cat. BRAVECTO PLUS is an extended-duration, broad-spectrum combination (fluralaner and moxidectin) topical solution for cats, indicated for both external … Specifically designed for the challenges of treating cats, BRAVECTO PLUS delivers everything that you expect from BRAVECTO and more. Greasy, oily, or wet appearance may occur at the application site in some cats. In well-controlled laboratory studies, Bravecto Plus was effective against naturally and experimentally induced adult and experimentally induced 4th stage larval and immature adult Toxocara cati and Ancylostoma tubaeforme infections in cats. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In addition, three treated cats (2/8 cats in the 1× group and 1/8 cats in the 3× group) developed adverse neurologic signs during the study and were euthanized due to quality-of-life concerns. Step 1: Immediately before use, open the pouch and remove the tube. As I opened the packaging I split some on my hands. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. Clinical signs in one cat in the 1× group included vomiting, depression, vocalization, and ataxia 38 days after dosing. Clinical signs in one cat in the 1X group included vomiting, depression, vocalization, and ataxia 38 days after dosing. Select one or more newsletters to continue. For topical use only. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. Do not contact or allow children to contact the application site until 2 hours post application. It binds to gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels of the nerves and muscles of the parasite resulting in hyperpolarization, paralysis and death. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. The kittens in the control group were administered saline orally. If contact with eyes occurs, then flush eyes slo… To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Merck Animal Health at 1-800-224-5318. In well-controlled laboratory studies, Bravecto Plus demonstrated >90% effectiveness against Dermacentor variabilis 48 hours after treatment or infestation for 2 months but failed to demonstrate ≥ 90% effectiveness beyond 2 months. Greasy, oily, or wet appearance may occur at the application site in some cats. Each milliliter contains 280 mg of fluralaner and 14 mg of moxidectin. Heartworms were found in the epidural space in the second cat of the 1× group and the cat in the 3× group. There are no known contraindications for the use of the product. Avoid oral ingestion. *ALT was greater than twice the upper reference range of 100 IU/L. Do not use directly on any skin lesions. Biochemical Data Summary. PubMed, In an oral safety study for fluralaner topical solution for cats, four out of six cats experienced coughing immediately after oral administration of the maximum labeled dose of 93.0 mg fluralaner/kg. Kills fleas, ticks, roundworms, hookworms and prevents heartworm disease for 2 months. Each tube is packaged individually in a pouch. A second cat in the 1× group had neurologic signs that included ataxia, paresis, and muscle tremors 25 days after dosing. Fluralaner, one of the ingredients in Bravecto Plus, is a member of the isoxazoline class. There were no clinically-relevant, treatment-related effects on body weights, clinical pathology (hematology, clinical chemistry, and coagulation profile), gross pathology or histopathology. November 2, 2020. If the product accidentally contacts skin and a sticky residue persists after washing, rubbing alcohol (70% isopropyl alcohol) can be applied to the area to remove the residue. Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. Citations, PRINCIPAL DISPLAY PANEL - 112.5 mg/5.6 mg Tube Pouch Carton, PRINCIPAL DISPLAY PANEL - 250 mg/12.5 mg Tube Pouch Carton, PRINCIPAL DISPLAY PANEL - 500 mg/25 mg Tube Pouch Carton, (What https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=d9d5ebde-7ff7-4864-b393-fbe77d7a112f, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. Doses of BRAVECTO® for dogs and BRAVECTO® for cats are counted separately and cannot be added together when determining rebate amounts. Each tube is packaged individually in a pouch. Part the hair and apply directly to the skin. In an oral safety study for fluralaner topical solution for cats, four out of six cats experienced coughing immediately after oral administration of the maximum labeled dose of 93.0 mg fluralaner/kg. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, or clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis). PLEASE NOTE: Rebate levels are based on the number of doses of the same product. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Bravecto for Cats has not been shown to be effective for 12-weeks duration in kittens less than 6 months of age. View Labeling Archives, Buy Bravecto Plus for cats online at Lowest Rate with Free Shipping in US. Not for human use. The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2- trifluoroethylamino)ethyl]benzamide. Single incidences of self-limiting hypersalivation in three kittens (one kitten in the 1X group and two kittens in the 3X group) and pruritus at the administration site in one kitten in the 3X group were observed on the day of dose administration. Hold the tube at the crimped end with the cap in an upright position (tip up). A second cat in the 1X group had neurologic signs that included ataxia, paresis, and muscle tremors 25 days after dosing. Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone, butylhydroxytoluene. Bravecto Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm (Toxocara cati; 4th stage larvae, immature adults and adults) and hookworm (Ancylostoma tubaeforme; 4th stage larvae, immature adults and adults). When fleas and ticks feed on your cat, they ingest Bravecto for Cats and die. The safety of Bravecto Plus has not been established in breeding, pregnant, and lactating cats. Single incidences of self-limiting hypersalivation in three kittens (one kitten in the 1× group and two kittens in the 3× group) and pruritus at the administration site in one kitten in the 3× group were observed on the day of dose administration. Every effort has been made to ensure the accuracy of the Bravecto Plus (fluralaner and moxidectin topical solution) for Cats information published above. In well-controlled laboratory studies, Bravecto Plus demonstrated ≥ 98.1% effectiveness against Ixodes scapularis 48 hours after treatment or infestation for 2 months. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Bravecto Plus for Cats is a safe and effective topical flea and tick treatment that treats fleas, ticks, gastrointestinal nematodes and prevents heartworm in cats. Do not store above 77°F (25°C). How to apply BRAVECTO Topical Solution for Cats A single dose should be applied to the skin on the back of the neck (separate fur if needed) with the easy Twist'n'Use ™ applicator once every 12 weeks. Compare. In well-controlled laboratory effectiveness studies, the following adverse reactions were seen after application of Bravecto Plus: pyrexia, tachypnea, mydriasis, pruritus, scabbing, and bloody stool. No adverse reactions were observed from the concurrent use of Bravecto Plus with other medications. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. Part the fur at the administration site. Bravecto Plus (fluralaner and moxidectin topical solution) for Cats. Add to Cart. Part the hair and apply directly to the skin. Fluralaner is an inhibitor of the arthropod nervous system. Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb - 27.5 lb (1.2 kg to 12.5 kg). Reg. If contact with eyes occurs, then flush eyes slowly and gently with water. Despite this, I obtained a replacement from the store and applied as directed. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. published 4 months ago. 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